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KMID : 0370219830270020149
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Yakhak Hoeji
1983 Volume.27 No. 2 p.149 ~ p.154
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The Effects of Hydrochlorothiazide on the Pharmacokinetics of Carteolol in Rabbits
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정혜주/Jeong HJ
조윤성/김낙두/고광호/Chough YS/Kim ND/Ko KH
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Abstract
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The effect of hydrochlorothiazide on the pharmacokinctics of carteolol in rabbits was studied. Animals were divided into two groups (group I and group II). Group I received carteolol (12mg/kg) and group II received carteolol (12mg/kg) with hydrochlorothiazide (20mg/kg) orally. The carteolol concentration in serum was measured by spectrofluorometric method and its pharmacokinetic parameter values were calculated. The serum concentration of carteolol in group II was significantly increased when compared with those in group I at 10 min (p<0.01), and at 30 min (p<0.05) after p.o. administration. In addition, the absorption rate constant of carteolol in group II was slightly increased and Tmax of carteolol in group II was significantly shortened (pCmax of carteolol in group II was significantly increased (p
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